Autistische Katatonie

    This site uses cookies. By continuing to browse this site, you are agreeing to our Cookie Policy.

    • Illi wrote:

      "The onset, which is often gradual, is between the ages of 10 and 19". Dann fällt meine Erfahrung also raus.
      Nicht unbedingt. In diesem Alter zeigen sich typischerweise die ersten Anzeichen (onset) dafür, z. B. Mutismus, verlangsamte Bewegungsabläufe, Regungslosigkeit, starke Passivität, ein Beispiel wäre stundenlanges regungsloses aus dem Fenster 'starren' etc.. Autistische Katatonie kann sehr wohl bei HFA/Asperger auch im Erwachsenenalter häufig auftreten, insbesondere wenn Kompensationsstrategien mit zunehmendem Alter versiegen und Overloads/Meltdowns zunehmen. Das Extrem der extremen Meltdowns führt zu einem neurologischen Komplettzusammenbruch und wenn diese(r) nicht regeneriert werden kann, evtl. zu einer akuten autistischen Katatonie. Jeder zehnte autistische Mensch ist davon betroffen.

      The post was edited 1 time, last by maksa ().

    • Fundiertes Webinar von Ruth Aspy Ph.D. / Barry Grossman Ph.D. zum Thema 'Autistische Katatonie' (2016):

      Catatonia and ASD: Hidden in Plain Sight - Part 1

      This webinar will provide information on how Catatonia is associated with ASD. It will review the characteristics of catatonia and the overlap with autism spectrum disorders. The presenters will provide an overview of the complex history of catatonia. Issues around Catatonia such as it can be can be life threatening, and requires its own treatment, will be covered.


      Catatonia and ASD: Hidden in Plain Sight - Part 2

      This presentation will provide additional information about Catatonia. Catatonia is a treatable condition that can be identified based on symptoms. Deterioration in psychomotor functioning and an increase in unresponsiveness are red flags for catatonia in ASD.Both medical and psychological interventions are recommended for individuals with ASD and
      catatonia.

      The post was edited 1 time, last by maksa ().

    • Catatonia in Autism Spectrum Disorder

      Downey, J. M., & McDonald, M. E., (2019). Clinical Corner: Catatonia in autism spectrum disorder. Science in Autism Treatment, 16(3).

      Eine gute Zusammenfassung, siehe:

      Display Spoiler

      Downey, J. M., & McDonald, M. E., (2019). Clinical Corner: Catatonia in autism spectrum disorder. Science in Autism Treatment, 16(3).

      Catatonia in Autism Spectrum Disorder

      Catatonia is a distinct cluster of mood, motor, vocal, and affective disorders that was first described by German psychiatrist, Karl Kahlbaum, in 1874 (Wachtel, 2013). Once thought to be solely a specifier for various psychotic and mood disorders such as schizophrenia, primary mood disorders, and mental disorders due to a general medical condition, it is now recognized in the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association, 2013) as an associated feature of autism spectrum disorder (ASD) and includes revised diagnostic criteria. Increases in catatonia research in ASD have resulted in the emergence of promising treatment interventions depending on the severity level of the symptoms (Dhossche, 2014).


      What does catatonia look like among individuals with ASD?

      Catatonia in ASD is also referred to as “catatonia-like deterioration in individuals with ASD” (Dhossche, Shah & Wing, 2006) or “autistic catatonia” (DeJong, Bunton & Hare, 2014). The onset of catatonia in individuals with ASD is insidious; there is a marked and obvious deterioration in movement, vocalizations, pattern of activities, self-care, and practical skills (Dhossche et al., 2006). More specifically, individuals typically exhibit slowed movement and verbalizations, slowed task initiation and completion, difficulty crossing thresholds, increased reliance on prompting, passivity and lack of motivation, Parkinsonian features such as akinesia and rigidity, day-night reversal, repetitive and ritualistic behaviors, and seemingly purposeless agitation/excitement (Shah & Wing, 2006).

      The onset of catatonia in ASD typically occurs between the ages of 15 and 20 with the average age about 18 years; however, a few cases have been reported outside the typical age range. In fact, research conducted by various medical and psychological professionals indicates an increase in recognition of pediatric catatonia (Dhossche, 2014). A limited number of studies suggest catatonia occurs in approximately 12-18% of adolescents and young adults with ASD although many researchers believe this number may be higher (Shah, 2016).

      Autistic catatonia may present as mild, moderate or severe, with symptoms fluctuating from day to day (Shah & Wing 2006). In its most severe form, the stability of the individual’s autonomic system is affected, potentially impacting heart rate, blood pressure, body temperature, digestion, metabolism (thus affecting body weight), urination and defecation (individuals become incontinent), breathing and swallowing. Total immobility is also a possibility, with reliance on others for all previously mastered self-help skills and activities of daily living. Individuals previously demonstrating some verbal skills may also become mute. The individual is at risk to lose a substantial amount of weight and experience dehydration due to decreased food and fluid intake. This severe presentation of catatonia-like deterioration in ASD necessitates hospitalization as the individual is at significant risk for serious medical morbidity and mortality (Shah & Wing, 2006).

      Individuals with moderate autistic catatonia present with limited mobility and a decrease in speech-language and communication skills, self-help skills and activities of daily living. These individuals exhibit extreme slowness in the ability to initiate, continue, and complete a task. The autonomic system may or may not be affected to some degree. The mild form of autistic catatonia is similar to the moderate form, but presents as less severe and does not typically involve the autonomic system.

      Some individuals with ASD exhibit precursor catatonia-like behaviors years before developing autistic catatonia; however, these are usually reported in hindsight. These precursors include socially passivity, a history of slowed movement, and slowness to initiate and respond. While the presence of these characteristics does not in and of itself predict a future comorbid diagnosis of catatonia, they are “red flags” necessitating increased observation and ongoing assessment. Because the development of autistic catatonia is a slow deterioration of the individual’s abilities, it behooves clinicians who are knowledgeable in early signs of catatonia-like symptoms to conduct a clinical observation and screening. These early steps will help guide intervention and appropriate referrals as soon as possible to reduce the potential exacerbation of catatonic symptoms (DeJong et al., 2014). An initial assessment is critical to ascertain the degree to which the catatonia-like deterioration has interfered with the individual’s everyday life, considering the impact on areas such as speech and communication, mobility, self-help skills, activities of daily living, leisure skills, and work or school.


      How is catatonia diagnosed?

      Characteristics of catatonia and ASD have some overlap in symptoms, such as repetitive behaviors, reliance on prompting, and seemingly purposeless agitation, which may lead to misdiagnosis or a failure to diagnose the condition. Two key factors when making a diagnosis are the emergence of new symptoms and/or a change in the type and pattern of premorbid functioning (Ghaziuddin, Quinlan, & Ghaziuddin, 2005). For example, reliance on prompting may significantly increase while the ability to execute previously mastered tasks, such as dressing oneself or completing a meal within a reasonable amount of time, significantly decreases. Essential components of evaluation include clinical observation, and the use of standardized and non-standardized assessments, including the Bush Francis Catatonia Screening Instrument (BFSI, 1996), a sub-test of the Bush, Fink, Petrides, Dowling, & Francis Rating Scale (BFCRS, 1996) by medical professionals and clinicians knowledgeable in the manifestations of autistic catatonia. The Shah and Wing (2006) “blueprint for the assessment of catatonia in ASD” may also be helpful in diagnosing the condition. The clinician must consider the entirety of the person’s history including parent, teacher and physician interviews, videos and data. The clinician should evaluate changes across many different areas, such as weight loss resulting from eating and/or drinking difficulties, toileting accidents, slowness and other abnormalities in motor movement, increased prompt dependency, reduction or loss of speech, and catatonia-like excitement (occurrences of inappropriate behavior, and behavior that is not within the individual’s control) (Shah & Wing, 2006).

      The “lorazepam challenge test” may be used to diagnose catatonia, particularly in individuals exhibiting the more severe form (Dhossche, 2014; Sienaert, Dhossche, Vancampfort, De Hert, & Gazdag, 2014). An individual suspected of having catatonia is administered one or two milligrams of lorazepam intravenously or intramuscularly. The test should be conducted when a diagnosis of catatonia is suspected (Sharma, Jena, Sharma, & Agrawal, 2014). A positive response to the test, which is rapid resolution of all catatonic symptoms, strongly supports a diagnosis of catatonia (Sienaert et al., 2014). Similarly, zolpidem, a non-benzodiazepine, is also used to diagnose and treat catatonia when there is a lack of response to lorazepam (Sienaert et al., 2014). Other medical conditions may play a role in the development of catatonia, including encephalitis, autoimmune diseases, biological factors, epilepsy, hormonal changes during puberty, and the use of antipsychotic medications (Dhossche, Shah, & Wing, 2006). Healthcare professionals must first rule out treatable causes when presented with an individual with ASD demonstrating catatonia-like symptoms. However, appropriate methods of treatment and management are imperative when a treatable underlying medical cause cannot be identified (Hare & Malone, 2004).

      Unfortunately, at this time few professionals are even aware this condition exists let alone qualified to conduct an appropriate clinical assessment, provide treatment recommendations, or make proper referrals. Untrained clinicians may lead to misdiagnosis and inappropriate interventions as professionals and caregivers may assume that the individual is engaging in these behaviors “on purpose” (Shah & Wing, 2006). It is critical to note that if the condition is not properly treated, an exacerbation and worsening of symptoms will occur. Therefore, referrals to professionals with knowledge and understanding of the nature of catatonia-like deterioration in individuals with ASD, and current evidence-based treatment options, are essential when the condition is suspected.


      How is catatonia in individuals with ASD treated?

      The evidence basis supporting the treatments for catatonia in individuals with ASD is limited, but growing. This section provides a review of the current research on treatment of autistic catatonia.

      Researchers, including Aspy and Grossman (2016), assert that true catatonic behaviors are motiveless and without function. However, this is not to suggest that teaching strategies and prompting techniques based on the principles of applied behavior analysis (ABA) are not of some benefit to individuals afflicted with this condition. In fact, clinicians trained in ABA and also educated about autistic catatonia would be able to recognize this syndrome and provide appropriate evaluation and therapeutic intervention, and/or make referrals to pertinent healthcare providers. A behavioral evaluation using functional assessment (FA) method, along with an initial assessment, are recommended to ascertain to what degree the catatonia-like deterioration has interfered with the individual’s everyday life and at what level (mild, moderate, or severe). Antecedent interventions, prompting strategies, and reinforcement are all effective components of treatment. For example, reinforcement can target adaptive behavior such as decreased time to complete a task or increased appropriate use of utensils when eating. The BFCRS (1996) is a recommended tool to be included as part of this evaluation to assess the severity level of the catatonia so appropriate methods and course of treatment can be implemented (Sienaert, et al., 2014).

      Individuals with autistic catatonia may benefit from the non-medical psychological approach and management principles described by Shah and Wing in 2006. The management principles provide strategies for each area potentially affected by catatonia such as incontinence, eating, drinking and swallowing, speech and communication, motor movement, and catatonia-like excitement. In addition to their “blueprint for assessment of catatonia in ASD”, Shah and Wing also developed a “blueprint for the treatment of catatonia in ASD” for all severity levels.

      Pharmacological treatments for catatonia include benzodiazepines, specifically lorazepam; it is the first choice of pharmacological treatment. Zolpidem, a non-benzodiazepine, is used when there is a lack of response to lorazepam. Some individuals with ASD presenting with catatonic symptoms may require a combination of the Shah and Wing (2006) approach and lorazepam or zolpidem (Dhossche, 2014).

      Electroconvulsive therapy (ECT) may be administered to individuals demonstrating the more severe form of catatonia-like deterioration who do not respond to the psychological approach and management principles or psychopharmacological treatment (Sienaert et al., 2014). Research to date indicates more effective alleviation of catatonic symptoms when administering bilateral ECT and/or high doses of Lorazepam as compared to other approaches, and should be strongly considered when treating the severe form of autistic catatonia as this severe form can be fatal. In some cases, symptoms of catatonia remain after treatment. In other cases, patients only experience partial response to treatment; that is, some symptoms are eradicated and some remain, or symptoms are somewhat alleviated, but not to baseline (pre-catatonia) levels. A systematic review of interventions by DeJong et al. (2014) found that decreased frequency of bilateral ECT and/or dosages of lorazepam following initial successful treatment often results in recurrence of some catatonic symptoms. Dhossche (2014) notes that in some cases maintenance bilateral ECT may be critical to reduce the recurrence of catatonic symptoms (Wachtel, Hermida & Dhossche, 2010).

      The DeJong et al. (2014) review determined the current body of research is promising, but indicate caution should be exercised when making recommendations for treatment. They strongly suggest the need for more robust, controlled, high quality studies to further determine the safety and effectiveness of these treatments. Dhossche (2014) asserts that these treatments are the best recommendations available at this time, based on clinical research, in order to attain positive outcomes. However, he indicates the need for the treatments to be gauged further as research increases. The authors of this “Clinical Corner“ article agree with Dhossche’s assessment based on their years of experience working with individuals with ASD who develop catatonia along with their clinical research.

      In summary, all staff and parents need to be properly trained in order to increase understanding and provide appropriate intervention. An increased awareness of the potential development of catatonia-like deterioration in individuals with ASD helps ensure appropriate assessment and treatment at the onset of the condition. When left untreated or improperly treated, the disorder can become chronic or develop into its most severe presentation. Knowledge gleaned by parents, medical professionals, special educators, clinicians, and all those working with individuals with ASD will decrease the likelihood that this debilitating condition will remain “hidden in plain sight” (Aspy & Grossman, 2015-16).

      References

      American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
      Aspy, R., & Grossman, B. G. (2015-2016). Catatonia and ASD: Hidden in plain sight. Retrieved from: cde.state.co.us/cdesped/catatonia_part01_ppt_2016-02-10.
      Bush, G., Fink, M., Petrides, G., Dowling, F., & Francis, A. (1996). Catatonia. I. Rating scale and standardized examination. Acta Psychiatrica Scandinavica, 93, 129-36.
      DeJong, H., Bunton, P., & Hare, D. J. (2014). A systematic review of interventions used to treat catatonic symptoms in people with autistic spectrum disorders. Journal of Autism and Developmental Disorders, 44, 2127-2136.
      Dhossche, D., Shah, A., & Wing, L. (2006). Blueprints for the assessment, treatment, and future study of catatonia in autism spectrum disorders. In: D. Dhossche, L. Wing, M. Ohta, & K. Neumarker, (Eds.), International Review of Neurobiology, 72, 267-284. New York, NY: Elsevier/Academic Press; 2006.
      Dhossche, D., Shah, A., & Wing, L. (2006). Blueprints for the assessment, treatment, and future study of catatonia in autism spectrum disorders. In: D. Dhossche, L. Wing, M. Ohta, & K. Neumarker, (Eds.), International Review of Neurobiology, 72, 270. New York, NY: Elsevier/Academic Press; 2006.
      Dhossche, D. (2014). Decalogue of catatonia in autism spectrum disorders. Frontiers in Psychiatry, 5, 157-162.
      Ghaziuddin, M., Quinlan, P., & Ghaziuddin, N. (2005). Catatonia in autism: A distinct subtype? Journal of Intellectual Disabilities, 49, 102-105.
      Hare, D. J., & Malone, C. (2004). Catatonia and autistic spectrum disorders. Autism, 8, 183-195.
      Shah, A. (2016). Catatonia and catatonia-type breakdown in autism. Retrieved from: network.autism.org.uk/good-pra…nia-type-breakdown-autism
      Shah, A., & Wing, L. (2006). Psychological approaches to chronic catatonia-like deterioration in autism spectrum disorders. International Review of Neurobiology, 72, 245-264.
      Sharma, C. M., Jena, S., Sharma, D., & Agrawal, R. P. (2014). Role of lorazepam challenge test in childhood catatonia. Journal of Pediatric Neurosciences, 3, 301-303.
      Sienaert, P., Dhossche, D., Vancampfort, D., De Hert, M., & Gazdag, G. (2014). A clinical review of the treatment of catatonia. Frontiers in Psychiatry, 5, 1-9.
      Wachtel, L. E., Hermida, A., & Dhossche, D. (2010). Maintenance electroconvulsive therapy in autistic catatonia: A case series review. Progress Neuro- Psychopharmacology Biology Psychiatry, 34, 581-587.
      Wachtel, L. E. (2013). Catatonia in autism. Presented at the Interagency Autism Coordinating Meeting. Baltimore, MD: Kennedy Krieger Institute; John Hopkins School of Medicine.


      Citation for this article:
      Downey, J. M., & McDonald, M. E., (2019). Clinical Corner: Catatonia in autism spectrum disorder. Science in Autism Treatment, 16(3).

    • Achtung, nicht weiterlesen, wenn du Wissenschaft suchst, hier kommt nur eine völlig ins Freie gedachte Theorie:

      - In Folge des Ersten Weltkriegs gab es hunderttausende Fälle von Katatonie, bekannt auch aus dem Film "Awakenings". Betroffen waren meist Jugendliche. Ein Zusammenhang mit der Spanischen Grippe wurde vermutet, aber nicht gefunden.
      - Long Covid: Neuropathie, vermutlich verursacht durch das eigene Immunsystem. Zeigt sich als schnelle Erschöpfbarkeit, Nebel im Kopf usw.
      - Autismus: auch bezeichnet als Neuropathie.

      Glyphosat und sicher auch andere Pflanzenvernichtungsmittel beruhen auf Nervengift.
    • Illi wrote:

      ... nicht weiterlesen, wenn du Wissenschaft suchst, hier kommt nur eine völlig ins Freie gedachte Theorie
      Allerdings :) wenn man schon einmal jemanden mit einer 'Autistischen Katatonie' erlebt hat, weiß man auch, dass diese ab einem bestimmten Punkt lebensbedrohlich ist und das hat dann gewiss nichts mehr mit schneller Erschöpfbarkeit, Nebel im Kopf oder Glyphosat :m(: zu tun, ebenso ist eine Autoimmunenzephalitis für Betroffene kein Spaß.
      Wir sprechen hier nun mal nicht von Nervengift und auch nicht von der Bezeichnung Neuropathie als Definition von Autismus (was sowieso fragwürdig zu betrachten ist und wohl auch nicht in diesen Thread gehört).
      'Autistische Katatonie' ist ein sehr sehr ernst zu nehmender Zustand über den bis dato relativ wenig bekannt ist und dieser Thread soll denjenigen helfen, die selbst und/oder deren Angehörige hierzu fundierte Information suchen, um Fehldiagnosen oder unterlassenen Diagnosen vorzubeugen, dies wurde ja bereits aufgezeigt, dass z. B. Neuroleptika bei autistischer Katatonie kontraindiziert sind, um dies einem 'Facharzt' der davon noch nie gehört hat nahe zu bringen bedarf es fundierter Information und keiner frei gedachter Theorien.
      Verzeihung, aber eine akute autistische Katatonie ist absolut kein Spaß, für alle Beteiligten!
    • @maksa Denkst du, long covid oder Autismus wären Spaß oder weniger ernst zu nehmen als Katatonie? In den von dir verlinkten Artikeln ist von Verhaltenstherapie und Anregung zu Aktivität als Therapieansätze für Katatonie die Rede. Da würde ich nicht gleich medikamentös ansetzen. Mir scheint, du hast einen übergroßen Respekt vor dem klinischen Bild.
      Ernährung wirkt auf den Körper mindestens so stark wie Medikamente und wir nehmen sie täglich zu uns. Jede Pathologie hat eine physiologische Seite, sonst könnte man sie ja auch gar nicht medikamentös behandeln. Also finde ich es interessant, was physiologisch dahinter steckt. Wenn du das nicht interessant findest, kannst du es ja ignorieren.
    • maksa wrote:

      dass z. B. Neuroleptika bei autistischer Katatonie kontraindiziert sind

      Illi wrote:

      Da würde ich nicht gleich medikamentös ansetzen.
      Sehr korrekt. Wenn die Artikel genau gelesen werden, weiß man, dass im Akutzustand Lorezpam verabreicht wird, ich habe davon gesprochen das Neuroleptika/Antipsychotika kontraindiziert sind bei autistischer Katatonie.
      Autismus ist per se nicht lebensbedrohlich, damit einhergehende 'autistische Katatonie' kann lebensbedrohlich sein!

      Illi wrote:

      Ernährung wirkt auf den Körper mindestens so stark wie Medikamente und wir nehmen sie täglich zu uns.
      Ernährung wirkt auf den Körper und hält ihn gesund. Klar. Medikamente wirken in ihrer Wirkstoffkonzentration bei weitem stärker, nimm' als Beispiel die obigen Neuroleptika und vergleiche sie mit einem gesunden Wildkräutersalat. Erstens was ist gesünder und zweitens was hat eine stärkere Wirkung? Für mich ist der Salat gesünder und das Neuroleptika hat bei weitem mehr Einfluss auf den Gehirnstoffwechsel, ob das gesund ist sei dahin gestellt.

      Illi wrote:

      Mir scheint, du hast einen übergroßen Respekt vor dem klinischen Bild.
      Verzeihung mir geht es nicht primär nur um ein klinisches Bild und abermals Verzeihung: vielleicht wird von Dir aus mangelnder Erfahrung eine autistische Katatonie um ein Vielfaches unterschätzt, wie gesagt:

      maksa wrote:

      wenn man schon einmal jemanden mit einer 'Autistischen Katatonie' erlebt hat, weiß man auch, dass diese ab einem bestimmten Punkt lebensbedrohlich ist und das hat dann gewiss nichts mehr mit schneller Erschöpfbarkeit, Nebel im Kopf oder Glyphosat zu tun
      Hier noch ein Erfahrungsbericht, den ich bewusst bisher nicht eingefügt habe, über eine ausbleibende Diagnose, Fehldiagnose, Missachtung der Menschenwürde und fahrlässige Unkenntnis und Fehlbehandlung einer 'autistische Katatonie':

      Illi wrote:

      Denkst du, long covid oder Autismus wären Spaß oder weniger ernst zu nehmen als Katatonie?
      Ne, aber Dein obiger Beitrag verharmlost (zumindest für mich) im Gegensatz dazu eine 'autistische Katatonie' durch verallgemeinernde Vergleiche, die nichts mit dem Thema zu tun haben. Wenn Du selbst schon einmal eine solche erlebt hättest, bzw. jemand in und durch eine solche begleitet hast, bin ich mir gewiss, dass Du Vergleiche dieser Art nicht ziehen würdest.
      Ich weiß von was ich spreche.
      Bitte sei so nett und respektiere das Thread-Thema.
      In diesem Thread geht es um 'autistische Katatonie' und nicht um Long Covid und Glyphosat, dazu gibt es andere Threads.

      Illi wrote:

      Also finde ich es interessant, was physiologisch dahinter steckt.
      Die genaue Ursache einer autistischen Katatonie ist unklar, Stress und Angst sind mit die hauptauslösenden neurophysiologischen Komponenten, auch gibt es Zusammenhänge mit GABA Neurotransmittern im Gehirn.
      Wenn Du mehr konkrete Informationen bezüglich der neurophysiologischen Hintergründe einer autistischen Katatonie kennst, würde ich mich freuen wenn Du sie hier teilst, aber bitte respektiere, dass es hier einfach nur um 'autistische Katatonie' geht und nicht um 'Kontroverse' und/oder

      Illi wrote:

      (d)eine völlig ins Freie gedachte Theorie
      Danke :)
    • @Illi Danke für Deinen interessanten link-Hinweis bezüglich Mikrobiom und GABA und den damit verbundenen Zusammenhängen zu Depressionen.

      (Allerdings konnte ich beim Lesen des kurzen Aufsatzes rein gar keinen Zusammenhang oder eine Erwähnung von und zu 'Glyphosat' erkennen. Wahrscheinlich ist jedoch, dass das Mikrobiom des Menschen durch Glyphosat bekanntlich stark in Mitleidenschaft gezogen wird, sicherlich gibt es hierzu auch diverse Studien ...
      nun ja aber das ist wie bereits erwähnt hier nicht Thema :) eröffne doch einen eigenen Thread zum Thema Glyphosat und Ernährung/Mikrobiom/Neurotransmitter, da dies evtl. auch interessante Aspekte für andere Forumsteilnehmer aufzeigen würde)

      The post was edited 1 time, last by maksa ().